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目的：探讨小剂量心得安与川芎嗪联用对肝硬化门脉高压犬血流动力学的影响及其作用机理。方法：在用药前后采用血管法检测９只肝硬化门脉高压犬血流动力学的变化，并检测其肝、肾功能。结果：小剂量心得安与川芎嗪联用３０分钟后，可使肝硬化犬肝静脉嵌塞压（ＷＨＶＰ）、肝静脉压力梯度（ＨＶＰＧ）及门静脉压（Ｐｐｖ）显著降低（ Ｐ ＜０．０５～００１），于６０分钟达最低点，但对平均动脉压（ＭＡＰ）、心率（ＨＲ）无明显影响，对肝、肾功能亦无不良影响。结论：小剂量心得安和川芎嗪联用可以有效降低门脉压力，没有明显副反应，值得临床试用并加以验证。
Objective: To investigate the effect of low dose of propranolol and ligustrazine on hemodynamics in cirrhotic portal hypertension dogs and its mechanism of action. Methods: The hemodynamics of nine cirrhotic patients with portal hypertension were measured by blood vessel method before and after treatment, and their liver and kidney function were tested. Results: WHVP, HVPG and Ppv in cirrhotic dogs were significantly decreased after treatment with LPS for 30 minutes (P <0.05) ~ 001) reached its lowest point at 60 minutes, but had no significant effect on mean arterial pressure (MAP) and heart rate (HR), nor did it have an adverse effect on liver and kidney function. Conclusion: The combination of low-dose propranolol and ligustrazine can effectively reduce the portal pressure without obvious side effects, which deserves clinical trial and verification.