产生肺部弥漫性病变的病因有100多种,其中大多数为可引起纤维化的肺间质性病变,故又统称为肺间质纤维化。原因已明的有吸入性(尘肺)、感染性、药物性、以及并发于全身性病变(胶原性疾病)者。原因不明的又称特发性肺间质纤维化或隐源性纤维性肺泡炎。特发性发病机制不明,现多数认为是一种自身免疫性疾病,与遗传因素亦可能有关,本病在国内并非罕见,随着认识的提高和经纤维支气管镜肺活检的开展,近年报告病例逐渐增多。由于本病早期治疗尚有一定疗效,而晚期实无良策。兼之误诊情况较为普遍,故早期诊断值得重视。 There are more than 100 causes of diffuse lung disease, most of which can cause fibrosis of interstitial lung disease, it is also collectively referred to as pulmonary fibrosis. The reasons for this are inhaled (pneumoconiosis), infectious, medicinal, and those complicated with systemic diseases (collagen diseases). For unknown reasons, also known as idiopathic pulmonary fibrosis or cryptogenic alveolar fibrosis. Idiopathic pathogenesis is unknown, the majority is considered to be an autoimmune disease, and genetic factors may also be related to the disease is not uncommon in the country, with the understanding and the development of bronchoscopic lung biopsy carried out in recent years, the reported cases Increasingly. Because of the disease early treatment is still a certain effect, but late no good policy. Both the misdiagnosis situation is more common, so early diagnosis deserves attention.