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目的:探讨吸烟成瘾青少年与非吸烟健康对照组大脑静息状态下脑功能自发活动的差异。方法:采用低频振荡振幅百分比方法(percent amplitude of fluctuation，perAF)对吸烟青少年(n n＝18)和非吸烟健康对照组(n n＝20)的静息态脑功能活动进行比较研究，采用Pearson相关分析探讨吸烟成瘾青少年perAF值的变化与烟龄、尼古丁成瘾评估得分(fagerstrom test for nicotine dependence，FTND)、吸烟量(包年数)的相关性。n 结果:与非吸烟健康对照组相比，吸烟成瘾青少年在海马旁回、颞中回及额上回的perAF值均显著增加(海马旁回：2.026 5±0.516 7比0.781 6±0.148 9；颞中回：0.796 7±0.203 2比0.545 5±0.134 1；额上回：2.734 5±0.372 8比1.962 4±0.416 8；均n P<0.001)。海马旁回perAF值的增加与吸烟成瘾青少年的烟龄呈显著负相关(n r＝-0.600 7，n P＝0.008 4)。n 结论:吸烟成瘾青少年的静息态脑功能局部活动强度增加，主要表现为海马旁回perAF值的显著增加，且该区域功能活动差异与吸烟者的吸烟年限有关，该发现有助于理解青少年吸烟成瘾的神经机制。“,”Objective:To investigate the differences of resting-state spontaneous neural activity between smoking addicted teenagers and healthy non-smokers.Methods:In the current study, the percent amplitude of fluctuation (perAF) approach was applied to explore the differences of resting-state spontaneous neural activity between smoking addicted teenagers and healthy non-smokers.Pearson correlation analysis was used to investigate the relationships between the altered perAF values and smoking years, fagerstrom test for nicotine dependence (FTND) and pack-years of smokers.Results:Compared with healthy non-smokers, smoking addicted teenagers showed increased perAF values in the parahippocampal gyrus (smoking addicted teenagers: 2.026 5±0.516 7, nonsmokers: 0.781 6±0.148 9), middle temporal gyrus (smoking addicted teenagers: 0.796 7±0.203 2, nonsmokers: 0.545 5±0.134 1), and superior frontal gyrus (smoking addicted teenagers: 2.734 5±0.372 8, nonsmokers: 1.962 4±0.416 8) (all n P<0.001). It was noteworthy that the perAF values of the parahippocampal gyrus were negatively correlated with smoking years of smoking addicted teenagers(n r=-0.6007, n P=0.0084).n Conclusion:Compared with healthy non-smokers, the resting-state regional neural activity in smoking addicted teenagers was altered, mainly manifested as increased perAF value in the parahippocampal gyrus, which is correlated with smoking years of smoking addicted teenagers.These findings may help us understanding neural mechanisms underlying nicotine addiction of smoking addicted teenagers.