目的　探讨E -和P -选择素与脑梗死的关系。方法　用ELISA方法测定 30例脑梗死、2 5例脑出血患者及2 8例正常人的sE -和sP -选择素血清水平 ,分析它们与WBC、N %、TNF及IL - 6血清水平之间的关系。结果　急性期脑梗死患者sE -和sP -选择素血清水平 [分别为 (6 5 2± 39 4)ng/ml、(399± 134)ng/ml]明显高于脑出血患者 [分别为 (4 4 6± 11 8)ng/ml、(2 43± 112 )ng/ml]及正常人 [分别为 (4 0 5± 12 5 )ng/ml、(2 2 7± 10 6 )ng/ml]。而该组患者恢复期这两种选择素水平无明显升高。急性期脑梗死患者sE -和sP -选择素水平分别与WBC、N %、IL - 6水平呈正相关关系 ,sP -选择素水平还与TNF水平呈正相关关系。结论　sE -和sP -选择素血清水平增高反映脑梗死急性期E -和P -选择素可能在TNF和IL - 6的刺激下 ,参与脑梗死损伤过程 Objective To investigate the relationship between E - and P - selectin and cerebral infarction. Methods Serum levels of sE - and sP - selectin in 30 patients with cerebral infarction, 25 patients with cerebral hemorrhage and 28 normal controls were measured by ELISA. The serum levels of sE - and sP - selectin between the two groups were compared with those of WBC, N%, TNF and IL - 6 Relationship. Results Serum levels of sE - and sP - selectin in patients with acute cerebral infarction were significantly higher than those in patients with intracerebral hemorrhage [(542 ± 394) ng / ml, (399 ± 134) ng / ml, respectively 4 6 ± 11 8 ng / ml, (2 43 ± 112) ng / ml] and normal subjects [(40 ± 125) ng / ml and (227 ± 10 6) ng / ml, respectively] . The two groups of patients with convalescent levels of selectin no significant increase. The levels of sE - and sP - selectin in patients with acute cerebral infarction were positively correlated with the levels of WBC, N% and IL - 6, respectively. The levels of sP - selectin were also positively correlated with the level of TNF. Conclusions The increase of sE - and sP - selectin serum levels may reflect that E - and P - selectin in the acute stage of cerebral infarction may be involved in the process of cerebral infarction injury stimulated by TNF and IL - 6