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右旋美托咪啶(dexmedetomidine,Dex)作为一种新型α2-肾上腺素能受体激动剂,具有良好的镇静效果和较少的术后不良反应。近年来随着对右旋美托咪啶的不断研究,该药在临床上得到了广泛应用,尤其在儿科麻醉广受好评。右旋美托咪啶在儿童的临床使用包括手术前用药、预防惊厥发生和儿童重症监护单元多重麻醉的使用等。本文就右旋美托咪啶最近的药理学研究和小儿临床麻醉应用研究等方面进行综述。
Dexmedetomidine (Dex), as a novel α2-adrenergic receptor agonist, has good sedation and less postoperative adverse reactions. In recent years, with the continuous study of dexmedetomidine, the drug has been widely used clinically, especially in pediatric anesthesia widely acclaimed. The clinical use of dexmedetomidine in children includes premedication, prevention of convulsions and the use of multiple anesthesia in critical care units in children. This article reviews the recent pharmacological studies of dexmedetomidine and pediatric clinical anesthesia.