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目的:观察艾迪莎联合自拟中药消溃愈疡汤灌肠治疗溃疡性结肠直肠炎的临床疗效。方法:将符合病例入选标准的溃疡性结肠直肠炎患者90例按就诊先后顺序随机分为观察组和对照组,每组45例。观察组以自拟消溃愈疡汤浓煎保留灌肠,1剂/d,每日早、晚各1次,同时口服艾迪莎1.0 g/次,3次/d。对照组单纯口服艾迪莎1.0 g/次,3次/d。2组均以1周为1个疗程,治疗2～3个疗程后观察疗效。结果:痊愈率观察组为55.56%,对照组为38.89%,2组相比差异有统计学意义(P<0.05);总有效率观察组为93.33%,对照组为78.89%,2组相比差异有统计学意义(P<0.05)。腹痛、腹泻、脓血便及里急后重等症状积分2组治疗前后组内相比差异有统计学意义(P<0.05),治疗后2组组间相比差异有统计学意义(P<0.05)。2组各有3例患者出现了恶心等不良反应(占3.33%),经对症治疗后均缓解。结论:艾迪莎联合自拟中药消溃愈疡汤灌肠治疗溃疡性结肠直肠炎疗效显著,可迅速改善症状、体征,且不良反应低。
Objective: To observe the clinical efficacy of Aidisha combined with self-made traditional Chinese medicine Xiao Ke Yu Yang Tang enema in the treatment of ulcerative colitis. Methods: Ninety patients with ulcerative colitis were enrolled and randomly divided into observation group and control group according to the order of treatment. Each group included 45 cases. In the observation group, the enema was preserved by decoction of ulcerative decoction with decoction of Yuyang Decoction for 1 time per day, morning and evening every day, and oral administration of Adesachax 1.0g / time for 3 times / d. The control group was orally administered with Adesa 1.0 g / time only, 3 times / d. The two groups were treated with 1 week for 1 week. After 2 to 3 courses of treatment, the curative effect was observed. Results: The cure rate was 55.56% in the observation group and 38.89% in the control group, with significant difference between the two groups (P <0.05). The total effective rate was 93.33% in the observation group and 78.89% in the control group. The difference was statistically significant (P <0.05). There were significant differences in scores of abdominal pain, diarrhea, abscess and tenesmus between the two groups before and after treatment (P <0.05). The difference between the two groups after treatment was statistically significant (P <0.05). Three patients in each group showed nausea and other adverse reactions (3.33%), and were relieved after symptomatic treatment. CONCLUSION: Adisseo combined with self-made traditional Chinese medicine Xiaopi Yuyang Decoction for the treatment of ulcerative colitis has significant curative effect, which can rapidly improve the symptoms and signs and has a low adverse reaction.