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有研究证明环磷酰胺 (ＣＰ)有强烈地致神经管畸形(ＮＴＤ)和骨骼发育异常等作用 ;亦有学者对其ＮＴＤ的发生率和致畸原因作了初步探讨[1～ 3] 。但尚未见有关ＮＴＤ与细胞凋亡相关的研究报道。本研究利用光镜和透射电镜观察了ＣＰ致ＮＴＤ与神经上皮细胞凋亡的关系 ,从形态学方
Studies have shown that cyclophosphamide (CP) has a strong cause of neural tube defects (NTD) and skeletal dysplasia and other effects; some scholars on its incidence of NTD and teratogenic causes were initially explored [1-3]. However, no studies have been reported on the association of NTD with apoptosis. In this study, the relationship between CP induced NTD and neuroepithelial cell apoptosis was observed by light microscopy and transmission electron microscopy. Morphology