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目的探讨合并感染肝吸虫对慢性乙型肝炎患者肝功能和病毒复制水平的影响。方法运用速率法和氧化法分别定量检测46例正常人、45例单纯肝吸虫感染患者、652例单纯慢性乙型肝炎患者和46例慢性乙型肝炎合并感染肝吸虫患者血清中的ALT、AST和TB的含量;同时运用荧光定量聚合酶链反应(FQ-PCR)检测慢性乙型肝炎患者的病毒复制指标HBV-DNA的水平。结果与正常组相比,慢乙肝组和肝吸虫组的ALT、AST和TB的表达水平明显升高,差异有统计学意义(P<0.05);与肝吸虫组相比,慢乙肝组ALT、AST和TB水平升高的幅度更大,差异有统计学意义(P<0.05);合并感染组ALT、AST和TB的表达水平明显高于慢乙肝组,差异有统计学意义(P<0.01),同时HBV-DNA的表达水平也升高,差异有统计学意义(P<0.05)。结论乙肝病毒感染和肝吸虫感染均会损害肝功能,但乙肝病毒对肝功能的损害更为严重,合并感染肝吸虫会进一步加重慢性乙型肝炎患者的肝功能损害,同时会促进乙型肝炎病毒的复制。研究结果可用来指导临床用药及选择正确的治疗方案来防控疾病。
Objective To investigate the effect of hepatic flu-infection on hepatic function and viral replication in chronic hepatitis B patients. Methods The rates of ALT, AST and AST in 46 normal individuals, 45 patients with simple infection of liver enzymes, 652 patients with chronic hepatitis B and 46 patients with chronic hepatitis B infection were assayed by the rate method and the oxidation method, respectively TB content; at the same time using fluorescent quantitative polymerase chain reaction (FQ-PCR) detection of chronic hepatitis B virus replication indicators HBV-DNA levels. Results Compared with the normal group, the expression levels of ALT, AST and TB in chronic hepatitis B and hepatic flukes group were significantly increased (P <0.05). Compared with the liver fluke group, ALT, The levels of AST and TB increased more significantly (P <0.05). The levels of ALT, AST and TB in the co-infected group were significantly higher than those in the chronic hepatitis B group (P <0.01) , While HBV-DNA expression levels also increased, the difference was statistically significant (P <0.05). Conclusion Hepatitis B virus infection and liver flu ’’ ’’ ’’ ’’ ’’ ’’ ’’ ’’ ’’ ’’ ’’ ’’ ’’ ’’ ’’ ’’ ’s’’ ’’ ’’ ’’ ’’ ’’ ’’ ’’ ’’ ’’ ’’ ’’ ’’ ’’ ’’ ’’ ’’ ’’ Copy. The results can be used to guide clinical medication and choose the correct treatment options to prevent and control the disease.