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本文报道口服国产尼可地尔治疗冠心病心绞痛患者21例,21例患者完成全过程观察。尼可地尔对控制心绞痛发作疗效有效率为86％,对冠心病高血压患者兼有降压作用。进行STI检查发现2/3患者的PEP/LVET比值缩短,4例患者进行放射性核素检查,LVEF测定均有增加,这反映收缩力及心功能得到改善,心电图改善不多。本文研究显示尼可地尔有解聚血小板的作用,这与抗心绞痛、防止心肌梗塞有益,并优于硝酸甘油。临床观察证明尼可地尔对心率无明显影响。该药吸收快、作用迅速、副作用轻微,长期服用安全范围大,有其一定实用价值。
This article reports the oral nicorandil treatment of coronary heart disease patients with 21 cases of angina pectoris, 21 patients completed the whole process of observation. Nicorandil is effective in controlling the onset of angina pectoris by 86% and has antihypertensive effects on patients with coronary heart disease and hypertension. Two-thirds of patients undergoing STI showed a shortened PEP / LVET ratio. Four patients underwent radionuclide examination and an increase in LVEF, reflecting improved contractility and cardiac function with little improvement in ECG. This study shows that Nicorandil has the effect of depolymerization of platelets, which is beneficial to anti-angina pectoris, prevention of myocardial infarction and superior to nitroglycerin. Clinical observation shows that nicorandil has no significant effect on heart rate. The drug absorbed quickly, the role of rapid, minor side effects, long-term use of safe range, with some practical value.