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目的 :观察三黄肾康丸对腺嘌呤致大鼠慢性肾衰 (CRF)的影响。方法 :连续喂养0 75 %腺嘌呤使Wister大鼠产生类似于人慢性肾衰的症状。2周后 ,治疗组大鼠每天用中药三黄肾康丸 (12 0g/kg、6.0g/kg)灌胃 ,连续6周 ,并于第4、8周测定大鼠血尿素氮 (BUN )、肌酐 (Scr)、RBC、HGB、HCT及肾脏病理学检查。结果 :三黄肾康丸明显改善大鼠肾衰的症状 ,与模型组大鼠比较 ,肾重量减轻 (P<0 01) ,纤维化程度降低 ,肾组织内结晶沉积物减少。结论 :三黄肾康丸对大鼠肾衰有明显治疗效果
Objective: To observe the effect of Sanhuang Shenkang Pill on adenine-induced chronic renal failure (CRF) in rats. METHODS: Continuous feeding of 75 % adenine caused Wister rats to produce symptoms similar to those of chronic renal failure. After 2 weeks, the rats in the treatment group were treated with traditional Chinese medicine Sanhuang Shenkang Pill (12 0g/kg, 6.0g/kg) daily for 6 weeks, and blood urea nitrogen (BUN) was measured at the 4th and 8th week. , Creatinine (Scr), RBC, HGB, HCT, and renal pathology. RESULTS: Sanhuang Shenkang Pill significantly improved the symptoms of renal failure in rats. Compared with the model group, the kidney weight was reduced (P<0.01), the degree of fibrosis was decreased, and the crystalline sediments in the kidney tissue were decreased. Conclusion : Sanhuang Shenkang Pill has obvious therapeutic effect on renal failure in rats