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目的 观察便通灵胶囊对正常小鼠和 3种便秘模型小鼠排便作用的影响 ,初步探讨其治疗便秘的作用机理。方法 根据文献所提供的方法造模 ,定时观察比较小鼠的胃肠的墨汁推进百分率、排便鼠数 ,以及排泻量等指标。结果 该胶囊对正常小鼠胃肠功能无明显影响 ;大剂量的便通灵胶囊能明显增加各种便秘证型小鼠的排便量 ,而小剂量则不明显。结论 便通灵胶囊具有较好的抗便秘作用 ,为临床应用及新药开发提供一定的根据。
Objective To observe the effect of Jietongling capsule on defecation in normal mice and three constipation model mice, and to explore the mechanism of its effect on constipation. Methods According to the methods provided in the literature, we regularly observed and compared the mice’s gastrointestinal percentage of ink advancement, the number of fecal droppings, and the volume of discharge. Results The capsule had no significant effect on the gastrointestinal function of normal mice; large doses of Tonglingling capsule could significantly increase the amount of defecation in mice with various constipation syndromes, while the small dose was not obvious. Conclusion Tong Tong Ling Capsule has good anti-constipation effect, providing a certain basis for clinical application and development of new drugs.