胆管闭锁是新生儿阻塞性黄疸最常见的原因之一,以肝内外胆管闭锁和梗阻性黄疸为特点,Kasai手术是其一线治疗方法,但最终仍有70%成功应用Kasai手术治疗的患儿发展为肝硬化,需要接受肝移植治疗[1-2]。胆管闭锁发病机制至今未明,研究多认为与肝内炎症反应,尤其是激活的CD4+细胞Th1亚型及其分泌的细胞因子介导的特异性炎症有关[3-5],有研究认 Biliary atresia is one of the most common causes of obstructive jaundice in neonates, characterized by intrahepatic biliary atresia and obstructive jaundice, and Kasai surgery is the first-line treatment, but eventually 70% of children with Kasai surgery still develop successfully For cirrhosis, need to accept liver transplantation [1-2]. The pathogenesis of biliary atresia has not yet been identified, and many studies have concluded that it is associated with intrahepatic inflammatory reaction, especially activated Th1 subtype of CD4 + cells and cytokine-induced specific inflammation secreted by them [3-5]