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为探讨龈沟液（ＧＣＦ）ＰＧＥ２含量与龈组织含量的关系，用放射免疫法测定了１５名成人牙周炎患者２０个部位ＧＣＦ和相应部位牙龈组织ＰＧＥ２含量．结果表明ＰＧＥ２含量：ＧＣＦ中为６９．２５±１７．２２ｐｇ／μｌ，相应牙龈组织为２２７．４７±３５．２２ｐｇ／ｍｇ湿重组织，ＧＣＦＰＧＥ２含量与相应龈组织ＰＧＥ２含量呈明显的正相关（ｒ＝０．９１９６，Ｐ＜０．０５）．提示ＧＣＦ中ＰＧＥ２含量可反映出龈组织ＰＧＥ２水平，为ＰＧＥ２在牙周病发病机制、病程进展、疗效判定等研究中提供了一敏感、无创伤、可反复取样、简单易行的可靠方法．
In order to investigate the relationship between the content of gingival crevicular fluid (PGE2) and the content of gingival tissue in gingival crevicular fluid (GCF), the content of GCF and the content of PGE2 in gingival tissue of 20 adult patients with periodontitis were determined by radioimmunoassay. The results showed that the content of PGE2 was 69.25 ± 17.22 pg / μl in GCF and 227.47 ± 35.22 pg / mg wet weight in corresponding gingival tissue. The content of GCFPGE2 was positively correlated with the content of PGE2 in gingival tissue (r = 0.9196, P <0.05). It is suggested that the content of PGE2 in GCF can reflect the level of PGE2 in gingival tissue. It provides a sensitive, non-invasive, reliable and reliable method for PGE2 in the pathogenesis of periodontal disease, progression of disease and judgment of curative effect.