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采用大鼠颈动脉－颈外静脉回路循环形成的血小板性动脉血栓，用兔脑粉浸出液诱导的大鼠下腔静脉血栓以及用凝血酶诱导的兔耳缘静脉血栓，作为实验性动脉及静脉血栓模型，并分别用阿斯匹林和尿激酶作为阳性对照药，以观察蕲蛇酶对血栓形成的影响。不同剂量的蕲蛇酶（６００，３００和１５０μｇ／ｋｇｉｖ）能使大鼠动脉和静脉血栓形成减少，并呈量效关系。蕲蛇酶对家兔耳缘静脉血栓形成亦表现抑制作用并促进血栓消褪。３００和６００μｇ／ｋｇ对家兔已形成的动脉和静脉血栓，能促使消褪，提示蕲蛇酶亦有溶栓作用
The rat thrombosis of thrombocytopenia was induced by the carotid-jugular venous circulation in rats. The inferior vena cava thrombus induced by rabbit brain leachate and the rabbit marginal venous thrombus induced by thrombin were used as experimental arterial and venous thrombosis Model, respectively, and aspirin and urokinase as a positive control drug, in order to observe the impact of viper enzyme on thrombosis. Different doses of viper enzyme (600,300 and 150μg / kgiv) can reduce arterial and venous thrombosis in rats, and the dose-response relationship. Acutobin also inhibits rabbit ear vein thrombosis and promotes thrombus fade. 300 and 600μg / kg of rabbit arteries and veins have formed thrombosis, can promote fade, suggesting that there is also a viper snake enzyme thrombolysis