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目的观察丹参在系统性红斑狼疮患者肝硬化进展中的作用。方法选择有肝损害的系统性红斑狼疮患者50例,随机分为治疗组25例与安慰剂组25例,治疗组在常规红斑狼疮治疗的基础上给予丹参注射液,安慰剂组只给予常规治疗并给予普通生理盐水作为安慰剂,同时选择25例无肝脏损害的系统性红斑狼疮患者作为对照组,观察3组治疗3个月后患者肝功能和肝纤维化以及血清中免疫球蛋白IgG等指标。结果治疗组肝功能各项指标及IgG水平均明显降低,肝纤维化各项指标也明显低于安慰剂组,差异有统计学意义(P﹤0.05)。治疗组与对照组相比,差异无统计学意义(P﹥0.05)。结论丹参能够明显抑制系统性红斑狼疮患者肝硬化的进展,对改善病情有显著作用。
Objective To observe the role of Salvia miltiorrhiza in the progression of liver cirrhosis in patients with systemic lupus erythematosus. Methods Fifty patients with systemic lupus erythematosus who had liver damage were randomly divided into treatment group (n = 25) and placebo group (n = 25). The treatment group was given Salvia miltiorrhiza injection on the basis of the treatment of conventional lupus erythematosus, while the placebo group was given conventional treatment 25 cases of systemic lupus erythematosus without liver damage were selected as the control group. The indexes of liver function, hepatic fibrosis and immunoglobulin IgG in serum were observed in 3 groups after 3 months treatment . Results All indexes of liver function and IgG in the treatment group were significantly decreased, and the indexes of liver fibrosis were also significantly lower than those in the placebo group, the difference was statistically significant (P <0.05). The difference between the treatment group and the control group was not statistically significant (P> 0.05). Conclusion Salvia miltiorrhiza can significantly inhibit the progression of liver cirrhosis in patients with systemic lupus erythematosus, and has a significant effect on improving the disease.