[Objective]The aim was to screen out chemicals with good control effect against Mycogone peniciosa Magn in Agaricus bisporus.[Method]M.peniciosa of A.bisporus was taken as the detection bacteria,and nine kinds of chemicals were conducted plate efficacy test in the laboratory.Mushroom house validation was carried out for the screened chemicals with strong inhibition to M.peniciosa.[Result]Nine kinds of chemicals had obvious difference in control effects on M.peniciosa and effects on growth of A.bisporus;2 400 and 3 200 times dilution of 78% Boer MZ WP and 2 400 times dilution of 69% Fulishuang WP after casing material processing had good control effects on M.peniciosa and had no apparent adverse effects on mycelial growth and fruiting development of A.bisporus.[Conclusion ]The 2 400 and 3 200 times dilution of 78% Boer MZ WP and 2 400 times dilution of 69% Fulishuang WP are worth popularizing. [Objective] The aim was to screen out chemicals with good control effect against Mycogone peniciosa Magn in Agaricus bisporus. [Method] M. peniciosa of A. bisporus was taken as the detection bacteria, and nine kinds of chemicals were conducted plate efficacy test in [Result] Nine kinds of chemicals had obvious difference in control effects on M. peniciosa and effects on growth of A. bisporus; 2 400 and 3 200 times dilution of 78% Boer MZ WP and 2 400 times dilution of 69% Fulishuang WP after casing material processing had good control effects on M.peniciosa and had no apparent adverse effects on mycelial growth and fruiting development of A. bisporus. [ The 2 400 and 3 200 times dilution of 78% Boer MZ WP and 2 400 times dilution of 69% Fulishuang WP are worth popularizing.