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目的通过梅毒血清学实验检测结果分析,了解本区域梅毒流行特征和方法学比较。方法依据2005～2007年我院进行梅毒血清学检测结果和2000年中国卫生部防疫司颁布的性病诊断标准,对临床梅毒进行分期;对阳性患者进行流行病学调查,同时评价TRUST、TP-ELISA和TPPA法特异性与敏感性。结果2005年梅毒血清学阳性率为2.7%,2006年为4.0%,2007年为8.7%;3年来Ⅰ期梅毒分别占55.9%、73.9%和61.3%,Ⅱ期梅毒分别占33.8%、20.4%和32.1%,Ⅲ期梅毒相对较少,隐性梅毒分别为8.8%、5.0%和6.0%;TRUST、ELISA和TPPA法敏感性分别为72%、87%和68%,特异性分别为88%、95%和100%。梅毒患者中男女比例为0.63:1,文化程度是初中和小学毕业占62%,其它38.0%,年龄分布主要在青壮年,职业分布是服务业和打工者占76.0%,其它占24.0%为主,婚姻状况已婚者占65.0%。结论梅毒血清学试验中敏感性ELISA法较高,特异性TPPA较高。
Objective To analyze syphilis epidemiology and methodology in this area through syphilis serology test results. Methods Based on the results of serological tests of syphilis in our hospital from 2005 to 2007 and the diagnostic criteria of venereal diseases issued by the Department of Epidemic Prevention of Chinese Ministry of Health in 2000, the clinical syphilis was staged. The positive patients were investigated by epidemiology, and the TRUST and TP-ELISA TPPA specificity and sensitivity. Results The positive rate of syphilis was 2.7% in 2005, 4.0% in 2006 and 8.7% in 2007. The prevalence of syphilis in stage Ⅰ was 55.9%, 73.9% and 61.3% respectively in the past three years, with 33.8% and 20.4% respectively in stage Ⅱ syphilis. And 32.1% respectively. The relative syphilis in stage Ⅲ was 8.8%, 5.0% and 6.0% respectively. The sensitivity of TRUST, ELISA and TPPA was 72%, 87% and 68% respectively, and the specificity was 88% , 95% and 100%. The proportion of male and female patients with syphilis was 0.63: 1. The educational level was 62% of junior high school and primary school, the other 38.0%. The age distribution was mainly in young and middle-aged. The occupational distribution was 76.0% for service industry and migrant workers, while the others accounted for 24.0% , Marital status married accounted for 65.0%. Conclusion Syphilis serological tests sensitive ELISA method is higher, specific TPPA higher.