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阿霉素的主要副作用是引发心脏毒性,此毒性作用与活性氧(ROS)有关。作者研究了叶下珠Phyl-lanthus urinaria L.(PU)对阿霉素心脏毒性的心肌细胞保护作用和抗氧化作用。将PU地上部分干粉制成乙醇提取物。试验采用大鼠心肌细胞H9c2。对PU分别进行了以下试验:Fe3+还原/抗氧化剂强
The major side effect of doxorubicin is the initiation of cardiotoxicity, which is associated with reactive oxygen species (ROS). The authors studied the protective and antioxidative effects of Phyllanthus urinaria L. (PU) on cardiomyocyte cytotoxicity of doxorubicin. The aboveground dry part of the PU was made into an ethanol extract. Rat cardiomyocytes H9c2 were used in the experiment. The following tests were separately performed on PUs: Fe3+ reduction/strong antioxidants