芬太尼透皮贴剂自1990年投放美国市场以来,已有120名使用过该药的患者相继死亡,以致人们非常关注这个新型强效镇痛药的临床应用安全性问题。尽管现有调查尚无确切结果,也无把药品召回或限制使用的计划,但美国、加拿大及中国的药监部门发布了公告,警示患者和医师必需严格遵循使用说明,以防过量致死及其他严重不良反应。 Since the launch of the fentanyl transdermal patch in the U.S. market in 1990, 120 patients who used the drug have died in the field, raising concerns about the clinical safety of the new potent analgesic. Although there is no definitive result and no plan to recall or restrict the use of drugs, the drug regulatory authorities in the United States, Canada and China issued a circular notifying patients and physicians that they must strictly follow the instructions for use in preventing over-lethal and other Serious adverse reactions.