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目的 比较干扰素 (IFN -α2 b)、丝裂霉素 C联合治疗及单用顺铂治疗恶性胸腔积液 (MPE)各 2 8例的临床疗效。方法 放干胸水后 ,胸腔内注射干扰素 90 0万单位、丝裂霉素 4m g或顺铂 30 m g,间隔 2 4～ 48小时后重复一次。结果 联合治疗的 2 8例 MPE中 ,完全缓解 2 1例 (75 .0 % ) ,总有效率达 89.3% ,而对照组顺铂完全缓解 11例 (39.3% ) ,总有效率仅为6 4.2 %。两组比较分别为 P<0 .0 1和 P<0 .0 5。结论 干扰素、丝裂霉素 C联合治疗 MPE具有较好的临床疗效。
Objective To compare the clinical efficacy of interferon (IFN-α2 b), mitomycin C combination therapy and cisplatin alone for 28 patients with malignant pleural effusion (MPE). Methods After pleural effusion was drained, 900 000 units of interferon, 4 mg of mitomycin, or 30 mg of cisplatin were intrapleurally injected and repeated at intervals of 24 to 48 hours. Results Of the 28 MPE cases treated with combination therapy, 21 cases (75.0%) were completely relieved, and the total effective rate was 89.3%, while the control group had 11 cases (39.3%) of complete remission of cisplatin. The total effective rate was only 64.2. %. The two groups were P 0. 01 and P 0. 05 respectively. Conclusion Interferon and mitomycin C combined with MPE have good clinical efficacy.