随着免疫细胞化学、分子生物学等检测技术的不断进展,恶性肿瘤微转移被发现是肿瘤发生发展过程中的早期事件,在乳腺癌和某些类型的肿瘤中,微转移的发生被认为是影响肿瘤患者预后的重要因素,对于指导个体化和系统化的治疗方式有着重要意义。本文就近年来在微转移检测方法和研究理论两方面的研究进展作一综述。 With the progress of detection technologies such as immunocytochemistry and molecular biology, micrometastases of malignant tumors have been found to be early events in tumorigenesis and development. In breast cancer and some types of tumors, micrometastasis is considered to be The important factors affecting the prognosis of cancer patients are of great significance for guiding the individualized and systematic treatment. This review summarizes recent advances in micrometastasis detection methods and research theories.