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目的探讨新疆维吾尔族人群5,10-亚甲基四氢叶酸还原酶(5,10-methylenetetrahydrofolate reductase,MTHFR)基因多态性与非酒精性脂肪肝(NAFLD)的相关因素。方法采用病例-对照研究,对维吾尔族NAFLD患者(NAFLD组,325例)和非NAFLD组(304例)MTHFR基因的rs1801131和rs1801133位点进行基因分型,用Logistic回归分析rs1801131和rs1801133位点多态性与新疆维吾尔族人群NAFLD的关系。结果在rs1801133基因位点的隐性模型中,AA基因型在NAFLD的发生过程中是风险因素(OR=2.023,P=0.033),在加性模型和显性模型下的基因型的分布差异无统计学意义(P<0.05)。在rs1801131基因位点的加性模型、显性模型和隐性模型下的基因型的分布差异无统计学意义(P>0.05)。结论维吾尔族人群中MTHFR基因rs1801133基因位点多态性与NAFLD的发生有关,AA基因型可能增加NAFLD的发病风险。
Objective To investigate the association of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism with non-alcoholic fatty liver disease (NAFLD) in Xinjiang Uygur population. Methods A case-control study was conducted to genotype the rs1801131 and rs1801133 loci of MTHFR gene in NAFLD patients (NAFLD group, 325 cases) and non-NAFLD patients (304 cases), Logistic regression was used to analyze rs1801131 and rs1801133 loci Relationship between NAFLD and Uigur Population in Xinjiang Uygur Autonomous Region. Results In the recessive model of rs1801133 locus, AA genotype was a risk factor for the development of NAFLD (OR = 2.023, P = 0.033). There was no significant difference in the genotype distribution between the additive and the dominant models Statistical significance (P <0.05). There was no significant difference in the distribution of genotypes between additive model, dominant model and recessive model of rs1801131 (P> 0.05). Conclusion The rs1801133 polymorphism of MTHFR gene in Uygur population is associated with the occurrence of NAFLD. The AA genotype may increase the risk of NAFLD.