肾间质纤维化对机体的影响不仅看纤维化的范围,还应看是否有细胞因子,特别是纤维化特异蛋白1的存在;肾间质纤维化发生与肾小管上皮转分化、多种细胞、细胞因子、血管紧张素Ⅱ、缺血缺氧等有关。过去认为基质金属蛋白酶降解细胞外基质,现发现有些基质金属蛋白酶促进肾纤维化。 The impact of renal interstitial fibrosis on the body not only look at the scope of fibrosis, but also to see if there are cytokines, especially the presence of fibrosis-specific protein 1; renal interstitial fibrosis and renal tubular epithelial transdifferentiation, a variety of cells , Cytokines, angiotensin Ⅱ, ischemia and hypoxia and so on. In the past that the matrix metalloproteinase degradation of the extracellular matrix, it was found that some of the matrix metalloproteinases promote renal fibrosis.