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目的利用空间自相关分析了解中国大陆地区苯丙酮尿症发生率的空间聚集性,以此来了解基因变异的遗传聚集性和基因变异的重点区域。方法利用GeoDa0.9.5-i(Beta)对2008~2010年中国大陆地区的30个省份的苯丙酮尿症检出率进行空间自相关分析,计算Moran’s I和LISA系数,得出聚集地图。结果 2008~2010年,苯丙酮尿症检出率的Moran’s I系数为0.3999,P为0.0010,表明总体检出率呈现正相关。LISA聚集地图显示其中有新疆、内蒙古、宁夏、甘肃等4个少数民族聚集省份呈现高高聚集现象。结论中国大陆地区的苯丙酮尿症的检出率呈现空间聚集性分布,提示地区差异可能会影响苯丙氨酸羟化酶基因的突变位点。
Objective To understand the spatial clustering of phenylketonuria incidence in mainland China using spatial autocorrelation analysis to understand the genetic clustering and gene mutation focus areas. Methods GeoDa0.9.5-i (Beta) was used to perform spatial autocorrelation analysis on the detection rate of phenylketonuria in 30 provinces of Mainland China from 2008 to 2010. The Moran’s I and LISA coefficients were calculated and the aggregated map was obtained. Results From 2008 to 2010, the detection rate of phenylketonuria Moran’s I coefficient was 0.3999, P 0.0011, indicating that the overall detection rate showed a positive correlation. LISA gathered map shows that there are Xinjiang, Inner Mongolia, Ningxia, Gansu and other four minority groups gathered in the province showed a high concentration phenomenon. Conclusions The detection rate of phenylketonuria in China is spatially aggregated, suggesting that the regional differences may affect the phenylalanine hydroxylase gene mutation sites.