支气管哮喘和慢性阻塞性肺疾病均是慢性气道炎症性疾病,尽管从发病机制到临床表现两者各有不同,但越来越多的研究表明两者在病因、发病机制和临床表现等诸多方面均有许多相似之处。解整合素-金属蛋白酶(a disintegrin and metalloprotease,ADAM)33基因作为首次通过定位克隆技术确定的哮喘易感基因,近几年的研究证实该基因与慢性阻塞性肺疾病的发生发展也有关联。ADAM33基因是否能架起哮喘和慢性阻塞性肺疾病共同发病机制的桥梁,笔者对近年来该基因的研究进展进行综述。 Both bronchial asthma and chronic obstructive pulmonary disease are chronic airway inflammatory diseases. Although there are differences between the pathogenesis and the clinical manifestations, more and more researches show that both of them have many causes such as etiology, pathogenesis and clinical manifestations There are many similarities. Disintegrin and metalloprotease (ADAM) 33 gene was the first susceptible gene for asthma identified by site-directed cloning. In recent years, it has been proved that ADAM33 gene is also associated with the development of chronic obstructive pulmonary disease. ADAM33 gene can set up a common pathogenesis of asthma and chronic obstructive pulmonary disease bridge, the author reviewed the progress of the gene in recent years.