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目的:探讨新生儿高胆红素血症对心肌酶活性的影响。方法:选择高胆红素血症的住院新生儿60例作为治疗组,40例同期出生的正常新生儿作为对照组,分别进行胆红素、心肌酶4项(天冬氨酸转氨酶、肌酸激酶、肌酸激酶同工酶和乳酸脱氢酶)、肌钙蛋白T及心电图检测。结果:新生儿胆红素越高心肌酶活性越高,治疗前和治疗后心肌酶活性比较差异有统计学意义(P<0.01)。随着胆红素的降低血清心肌酶活性明显降低,与正常对照组之间差异无统计学意义(P>0.05)。结论:新生儿高胆红素血症能引起心肌酶活性的升高,但不一定造成患儿心肌细胞不可逆损伤,儿科医生在判断黄胆对心肌有无损伤时除进行心电图检查外,还要将心肌酶和肌钙蛋白T列为常规检测项目,避免新生黄胆患儿因心肌损伤而死亡。
Objective: To investigate the effect of neonatal hyperbilirubinemia on myocardial enzyme activity. Methods: 60 neonates with hyperbilirubinemia were selected as the treatment group and 40 normal newborn infants born at the same period as the control group. Four bilirubin and myocardial enzymes (aspartate aminotransferase, creatine Kinase, creatine kinase isoenzyme and lactate dehydrogenase), troponin T and electrocardiogram. Results: The higher neonatal bilirubin higher myocardial enzyme activity, before and after treatment, myocardial enzyme activity difference was statistically significant (P <0.01). With the decrease of serum bilirubin, serum myocardial enzyme activity was significantly lower than that of the normal control group, with no significant difference (P> 0.05). Conclusions: Neonatal hyperbilirubinemia can cause the increase of myocardial enzyme activity, but it may not cause irreversible damage of cardiomyocytes in children. Pediatricians should not only check ECG when there is no damage to the myocardium, Myocardial enzymes and troponin T as a routine test items to prevent neonatal jaundice in children due to myocardial injury and death.