A series of 6-fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo[4,3-c]quinoline-2-carboxamide derivatives was designed based on the bioisosterism and combination principle in drug design.The target compounds were synthesized from substituted aniline through Michael addition,eyclization,Mannich reaction and condensation with 4-substituted semicarbazides,and the structures were confirmed by mass spectrometry(MS)and 1H NMR.The antifungal assay was carried out in vitro by two-fold dilution.The result shows that all the compounds are of antifungal activities against the tested fungi at different levels.