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目的探讨良性前列腺增生(BPH)伴组织学炎症与前列腺特异性抗原(PSA)异常升高的关系。方法取100例BPH患者前列腺组织行常规HE染色,观察其合并前列腺炎情况。并行免疫组化分析检测炎症相关因子IL-2、类血友病因子(vWF)及其平滑肌α-肌动蛋白(α-SMA)和上皮细胞钙黏蛋白(E-cadherin)指标变化,比较炎症的分级及侵袭度与PSA之间的关系。结果100例BPH患者中,术后病理均认为伴有不同程度的前列腺炎症。相关性分析显示,PSA与前列腺体积、炎症分级、侵袭度分级均呈正相关,炎症分级与α-SMA、E-cadherin呈负相关,与IL-2呈正相关(P均<0.05)。结论 BPH患者都伴随有前列腺炎,PSA与炎症分级、侵袭度分级均有相关性,提示炎症可能是导致前列腺组织增生的原因之一。
Objective To investigate the relationship between benign prostatic hyperplasia (BPH) with histological inflammation and abnormal prostate-specific antigen (PSA). Methods 100 cases of BPH patients with normal prostate tissue HE staining, observe the situation with prostatitis. The expression of IL-2, vWF, α-SMA and E-cadherin were detected by immunohistochemical analysis. Inflammatory factors The relationship between grade and invasiveness and PSA. Results 100 cases of BPH patients, postoperative pathology are considered with varying degrees of prostatitis. Correlation analysis showed that there was a positive correlation between PSA and prostate volume, grade of inflammation and grade of invasion. The grade of inflammation was negatively correlated with α-SMA and E-cadherin, and positively correlated with IL-2 (all P <0.05). Conclusions BPH patients are accompanied by prostatitis. The correlation between PSA and inflammation grade and grade of invasion indicates that inflammation may be one of the causes of prostatic hyperplasia.