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我们采用噬菌体诱导试验、Ames 试验、SOS 固体显色试验联合检测临床常用的22种抗肿瘤药物的致突变性。并以检出的致突变阳性药物为靶剂,对60种中药材、果蔬等天然物质做了抗突变试验,筛选出了有应用前途的拮抗剂。材料与方法1 材料1.1 致突变试验被检抗肿瘤药物收集医院正在应用的22种抗肿瘤药物,以5倍稀释法稀释成5种不同浓度。
We used phage induction test, Ames test, SOS solid color test combined detection of 22 commonly used in clinical anti-tumor drug mutagenicity. Mutagenicity-positive drugs were detected as targets, and 60 kinds of traditional Chinese medicines, fruits and vegetables were tested for their mutagenicity, and promising antagonists were screened out. MATERIALS AND METHODS 1 MATERIALS 1.1 Mutagenicity Tests Antineoplastic Agents Twenty-two antineoplastic agents currently in use at the hospital were collected and diluted to five different concentrations by 5-fold dilution.