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Objective To investigate the mechanism of inflammation of smooth muscle cells induced by oxidized lowdensity lipoprotein through Sirt1 in the atherosclerosis.Methods The expression of Sirt1 had been measured in the plaque tissues of human and mice.The affection of overexpression of SIRT1 on the ox LDL induced-inflammatory response and ROS generation had been detected in this study.Results Sirt1 decreased in smooth muscle
Objective To investigate the mechanism of inflammation of smooth muscle cells induced by oxidized low density lipoprotein through Sirt1 in the atherosclerosis. Methods The expression of Sirt1 had been measured in the plaque tissues of human and mice. The affection of overexpression of SIRT1 on the ox LDL induced -inflammatory response and ROS generation had been detected in this study. Results Sirt1 decreased in smooth muscle