大耳白兔３０只均分三组，对照组饲正常饲料，致石组饲含１．２％胆固醇和０．５％胆盐的高胆固醇饲料及麦芽糖糊，防石组饲高胆固醇饲料及正醇。一月后心脏穿刺测甘油三酯及胆固醇，并剖腹取胆囊及肝胆管胆汁测各种胆汁成分。结果：防石组血清胆固醇和胆囊胆汁中胆固醇、磷脂、钙等明显低于致石组，提示饮酒对胆固醇结石有预防作用。 Large white rabbits 30 were divided into three groups, the control group fed normal feed, caused by the stone group fed with 1.2% cholesterol and 0.5% bile salt of high cholesterol feed and maltose paste, anti-stone group fed high cholesterol diet and Is alcohol. After January, triglyceride and cholesterol were measured by cardiac puncture and various bile components were measured by cesarean section and cholangiopancreatography. Results: The levels of cholesterol, phospholipid and calcium in serum cholesterol and gallbladder in anti-stone group were significantly lower than those in stone group, suggesting that drinking alcohol had a preventive effect on cholesterol gallstone.