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目的:观察脐血输注对恶性肿瘤患者化疗后骨髓功能的保护作用。方法:90例患者随机分为治疗组和对照组,其中治疗组44例,对照组46例。治疗组当白细胞下降至度时开始静脉输注脐血,每天1～3单位,连用2～7d;在白细胞下降至度以下时加用造血细胞集落刺激因子(G-CSF),对照组在白细胞下降时不接受脐血输注,其他治疗同治疗组。结果:两组病人化疗后、度白细胞下降发生率分别为84.1%,50%和86.9%,52.1%,差异无显著意义(P>0.05);治疗组白细胞恢复正常所需时间为(7.4±3.5)d,短于对照组(11.5±4.3)d,差异有统计学意义(P<0.05)。输血反应发生率为1.3%。结论:本观察结果提示脐血输注未能明显地阻止白细胞的进一步下降,但可显著缩短白细胞恢复时间,表明脐血输注对化疗后的骨髓功能有良好的保护作用,而且脐血输注安全,值得推广。
Objective: To observe the protective effect of cord blood transfusion on bone marrow function after chemotherapy in patients with malignant tumors. Methods: Ninety patients were randomly divided into treatment group and control group, including 44 cases in treatment group and 46 cases in control group. In the treatment group, umbilical cord blood was infused once every day when the number of leukocytes dropped to degrees, 1 to 3 units per day for 2 to 7 days; hematopoietic colony-stimulating factor (G-CSF) was added when the number of leukocytes decreased to below, and the control group was leukocytes. Umbilical blood infusion was not accepted at the time of the fall, and other treatments were in the same treatment group. Results: The incidence of leukopenia after chemotherapy in the two groups was 84.1%, 50%, 86.9%, and 52.1%, respectively; the difference was not significant (P>0.05); the time required for the leukocyte to return to normal in the treatment group was (7.4±3.5). )d, shorter than the control group (11.5±4.3) d, the difference was statistically significant (P<0.05). The incidence of transfusion reactions was 1.3%. Conclusion: This observation suggests that umbilical cord blood transfusion can not significantly prevent the further decline of white blood cells, but can significantly shorten the recovery time of leukocytes, indicating that cord blood transfusion has a good protective effect on bone marrow function after chemotherapy, and cord blood transfusion Safe, worth promoting.