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目的探讨TGF-β1和P53在人结肠癌组织中的表达及其意义。方法通过免疫组织化学染色法检测53例结肠癌组织,32例结肠腺瘤组织及10例癌旁正常结肠中TGF-β1和P53的表达及其相互关系。结果TGF-β1和P53阳性表达在结肠癌组织中(62.26%,69.81%)均显著性高于癌旁正常结肠组织(10%,10%)和结肠腺瘤组织(15.63%,21.88%),差异均有统计学意义(P<0.05)。TGF-β1和P53在淋巴结转移组的阳性率(78.57%,85.71%)高于无淋巴结转移组(44.0%,52.0%),差异均有统计学意义(P<0.05)。TGF-β1和P53在结肠癌组织中表达有相关性(r=0.6528,P<0.05)。结论TGF-β1和P53可能参与了肿瘤生长和发展的共同通道,在大肠癌的发生、发展和转移过程中起着重要作用。
Objective To investigate the expression of TGF-β1 and P53 in human colon carcinoma and its significance. Methods Immunohistochemical staining was used to detect the expression of TGF-β1 and P53 in 53 cases of colon cancer, 32 cases of colon adenoma and 10 cases of adjacent normal colorectal mucosa. Results The positive expressions of TGF-β1 and P53 were significantly higher in colon cancer tissues (62.26%, 69.81%) than in adjacent normal colon tissues (10%, 10%) and colon adenomas (15.63%, 21.88% The differences were statistically significant (P <0.05). The positive rates of TGF-β1 and P53 in lymph node metastasis group (78.57%, 85.71%) were significantly higher than those in non-lymph node metastasis group (44.0%, 52.0%) (P <0.05). The expression of TGF-β1 and P53 in colon cancer tissues was correlated (r = 0.6528, P <0.05). Conclusion TGF-β1 and P53 may be involved in the common pathway of tumor growth and development, which play an important role in the carcinogenesis, development and metastasis of colorectal cancer.