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目的探究p53基因第72位密码子(codon72)多态性与HPV相关食管鳞癌的关联性。方法选择435例食管鳞癌(Esophageal Squamous Cell Carcinoma,ESCC)患者和550例健康对照,进行p53 codon72与食管鳞癌发生的关联研究。结果病例组的Arg/Arg基因型的频率高于对照组(85.7%vs 49.6%);Arg/Arg基因型携带者发生食管鳞癌的风险是携带Arg/Pro或Pro/Pro基因型个体的6.48倍(P<0.001)。结论 p53 co-don72纯合子Arg/Arg可能是HPV相关食管鳞癌发生的危险因素。
Objective To investigate the association between codon72 polymorphism of p53 gene and HPV-related esophageal squamous cell carcinoma. Methods A total of 435 Esophageal Squamous Cell Carcinoma (ESCC) patients and 550 healthy controls were selected for the study of association between p53 codon72 and esophageal squamous cell carcinoma. Results The frequency of Arg / Arg genotype in case group was higher than that in control group (85.7% vs 49.6%). The risk of esophageal squamous cell carcinoma was 6.48 in Arg / Pro or Pro / Pro genotype Times (P <0.001). Conclusion Arg / Arg, a p53 co-don72 homozygote, may be a risk factor for HPV-related esophageal squamous cell carcinoma.