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目的通过对12例艾滋病(AIDS)合并马尔尼菲青霉病(PSM)临床资料的分析,提高对该病的认识。方法回顾分析2002年11月至2003年11月收治的12例AIDS合并PSM的住院患者的资料。PSM的确诊依靠培养和病理检查。结果本组患者以反复发热、咳嗽、消瘦、腹泻、贫血、淋巴结肿大,皮肤损害尤其是皮肤坏死性丘疹为临床特点,外周血CD4计数均少于0.1×109/L。结论遇上述情况时应考虑PSM并行相关检查,此对PSM的早期诊断、早期治疗和改善预后有重要意义。本组1例极可能是江西首次发现的AIDS合并PSM。
Objective To analyze the clinical data of 12 cases of AIDS combined with Penicillium marneffei (PSM) to improve the understanding of the disease. Methods The data of 12 inpatients with AIDS complicated with PSM admitted from November 2002 to November 2003 were retrospectively analyzed. The diagnosis of PSM depends on the culture and pathological examination. Results The patients with fever, cough, weight loss, diarrhea, anemia, lymph nodes, skin lesions, especially skin necrosis papillary clinical features, peripheral blood CD4 count were less than 0.1 × 109 / L. Conclusion In the above cases, PSM should be considered in parallel, which is of great significance for the early diagnosis, early treatment and prognosis of PSM. One patient in this group is most likely the AIDS-associated PSM found in Jiangxi.