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慢性肝脏疾患时骨骼病变的原因尚无定论。作者对8例组织学证实的肝炎后及原因不明的肝硬化(男5、女3例,年龄49～60岁)进行了血清25-羟基维生素 D(25-OH-D)、1α,25-二羟基维生素 D[1α,25-(OH)_2-D]、钙、磷、肌酐、甲状旁腺激素及尿肌酐的测定。采血限于11月～2月的冬季,空腹。同时以年龄相仿的10例健康人作为对照组。结果健康人空腹血清25-OH-D 浓度为24.7±1.1ng/ml,肝硬化患者明显增高,为40.8±4.9ng/ml;两者的1α,25-(OH)_2-D 分别为43.3±0.8
The cause of skeletal lesions in chronic liver disease is inconclusive. The authors evaluated the serum levels of 25-hydroxyvitamin D (25-OH-D), 1α, 25-hydroxyvitamin D in 8 patients with histologically proven hepatitis and unexplained cirrhosis (3 males, 3 females and 49 to 60 years of age) Dihydroxyvitamin D [1α, 25- (OH) _2-D], calcium, phosphorus, creatinine, parathyroid hormone and urinary creatinine. Blood collection is limited to winter from November to February, fasting. At the same time, 10 healthy people of similar age were taken as the control group. Results The fasting serum 25-OH-D concentration in healthy volunteers was 24.7 ± 1.1ng / ml, and the patients with cirrhosis were significantly higher (40.8 ± 4.9ng / ml). The 1α, 25- (OH) 0.8