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高海拔地区由于高原低氧常引起红细胞增生过度,导致高原红细胞增多症(HAPC)。青海地处青藏高原,海拔平均在4 500m以上,发生HAPC的患者也较中国其他地区增多,给当地人民群众带来了许多健康危害。其中对心肺功能影响已得到认可,但对肾脏的影响目前无可靠的理论知识支持,也缺乏肾脏组织病理学诊断直观的第一手资料。本文通过对红细胞增多症的不同类型初步探讨阐述其引起肾损伤的机制,并探讨红细胞增多症引起的肾损害的治疗方案。另一方面通过肾脏病理诊断,提示高原红细胞增多症HAPC一样可能影响肾脏功能并能引起临床症状及肾脏组织病变,即出现“HAPC肾损害”。
High altitude often cause hyperplasia of erythrocytes due to hypoxia on the plateau, leading to high altitude polycythemia (HAPC). Qinghai is located on the Qinghai-Tibet Plateau, with an average altitude of more than 4 500m. HAPC patients are also more than other parts of China, bringing many health hazards to the local people. The impact on cardiopulmonary function has been recognized, but the impact on the kidney is currently no reliable theoretical knowledge, but also the lack of first-hand information on the histopathological diagnosis of kidney intuitive. In this paper, the different types of polycythemia preliminary discussion of its mechanism of causing renal damage and explore the treatment of renal damage caused by polycythemia treatment. On the other hand through the pathological diagnosis of renal disease, suggesting that high altitude polycythemia HAPC may affect renal function and can cause clinical symptoms and renal tissue lesions, that is, “HAPC renal damage.”