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目的探讨急性脑梗死伴脑内微出血患者血脂水平、β-淀粉样蛋白(β-AP)水平及其与脑内微出血的关系。方法选取2011年1月~2013年12月广东省河源市龙川县人民医院脑梗死患者98例,将其分为脑内微出血组(46例)和非脑内微出血组(52例),另选择健康人50例为对照组。46例脑内微出血患者中,轻度20例,中度16例,重度10例。检测总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)、血清β-AP水平,并对血脂、血清β-AP水平与年龄、脑内微出血、脑内微出血严重程度、体重指数进行相关性分析。结果脑内微出血组血清TC、TG、LDL-C、β-AP水平均高于非脑内微出血组和对照组,差异有高度统计学意义(P<0.01),非脑内微出血组血清TC、TG、LDL-C、β-AP水平高于对照组,差异有高度统计学意义(P<0.01);但脑内微出血组HDL-C水平明显低于非脑内微出血组和对照组,差异有高度统计学意义(P<0.01),非脑内微出血组HDL-C水平低于对照组(P<0.01)。随着脑内微出血严重程度加重,血清TC、TG、LDL-C、β-AP水平均明显上升,差异有高度统计学意义(P<0.01);随着脑内微出血严重程度加重,血清HDL-C水平明显下降,差异有高度统计学意义(P<0.01);血清TC、TG、LDL-C、β-AP水平与脑内微出血、脑内微出血严重程度均呈正相关(r=0.25~0.45,P<0.05);HDL-C水平与脑内微出血、脑内微出血严重程度呈负相关(r=-0.36、-0.32,P<0.05)。结论血脂、β-AP在脑内微出血患者血清中存在异常表达,与脑内微出血发病及病情进展密切相关。
Objective To investigate the relationship between serum levels of β-amyloid (β-AP) and micro-hemorrhage in patients with acute cerebral infarction and intracerebral hemorrhage. Methods From January 2011 to December 2013, 98 patients with cerebral infarction in Longchuan County People’s Hospital of Heyuan City, Guangdong Province were divided into intracerebral hemorrhage (46 cases) and non-intracerebral hemorrhage (52 cases) , And another 50 healthy people as the control group. Among the 46 patients with intracerebral hemorrhage, 20 were mild, 16 were moderate, and 10 were severe. (TC), triglyceride (TG), LDL-C, HDL-C and serum β-AP levels were measured and the level of serum lipids, serum β-AP Level and age, intracerebral hemorrhage, intracerebral hemorrhage severity, body mass index were analyzed. Results The levels of TC, TG, LDL-C and β-AP in the intracerebral hemorrhage group were significantly higher than those in the non-intracerebral hemorrhage group and the control group (P <0.01). The non-intracerebral hemorrhage group The levels of serum TC, TG, LDL-C, and β-AP were higher than those in the control group (P <0.01), but the levels of HDL-C in the intracerebral hemorrhage group were significantly lower than those in the non-intracerebral hemorrhage group The difference was statistically significant (P <0.01). The level of HDL-C in non-intracerebral hemorrhage group was lower than that in control group (P <0.01). Serum levels of TC, TG, LDL-C and β-AP were significantly increased with the severity of intracerebral hemorrhage (P <0.01). With the aggravating severity of intracerebral hemorrhage, serum (P <0.01). The levels of serum TC, TG, LDL-C, and β-AP were positively correlated with micro-hemorrhage in the brain and the severity of micro-hemorrhage in the brain (r = 0.25-0.45, P <0.05). The level of HDL-C was negatively correlated with micro-hemorrhage in the brain and the severity of micro-hemorrhage in the brain (r = -0.36, -0.32, P <0.05). Conclusion Serum lipids and β-AP are abnormally expressed in sera of patients with intracerebral hemorrhage, which is closely related to the onset of intracerebral hemorrhage and the progression of the disease.