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目的:观察腰六俞穴位埋线结合导引术和腰腿痹通胶囊对腰椎间盘突出症患者血清肿瘤坏死因子-α( TNF-α)和一氧化氮( NO)的影响。方法将158例腰椎间盘突出症患者随机分为两组,观察组79例,采用腰六俞穴位埋线导引术配合口服腰腿痹通胶囊治疗;对照组79例,采用单纯针灸治疗;两组采取相同穴位:肾俞、气海俞、大肠俞。治疗前后均进行TNF-α、NO含量检测,并用t检验方法进行统计学分析。结果治疗后两组血清TNF-α含量均呈下降趋势,但观察组明显降低,且接近常值水平, NO均呈上升趋势,但观察组明显升高,与治疗前比较,有极显著差异(P<0.01),与对照组比较,有显著性差异(P<0.05)。结论腰六俞穴位埋线结合导引术和腰腿痹通胶囊对腰椎间盘突出症患者血清TNF-α及NO恢复平衡,从而维持正常的血管舒缩功能,改善局部供血情况,缓解局部肌肉痉挛。“,”s:Objective To observe the effect of acupoint catgut embedding therapy combined with guided operation and Yaotui Bitong capsule on serum tumor necrosis factorαand nitric oxide(NO) in patients with lumbar intervertebral disc herniation(LIDH).Methods 158 cases of patients with LIDH were randomly divided into 2 groups, 79 cases in observation group received waist Liushu acupoint catgut em-bedding therapy combined with oral Yaotuibitong capsule;79 cases in control group received simple acupuncture treatment;both groups were taken the same acupoints:Shenshu, Qihaishu, Dachangshu.The contents of NO and TNF-αwere detected before and after treatment, the statistical analysis was performed by t test.Results After treatment, serum TNF-αcontent of both groups decreased, observation group decreased more significantly and closer to normal level, NO showed an upward trend, observation group increased more significantly, com-pared with before treatment, there were significant difference (P<0.01), compared with control group, there was significant difference (P<0.05) .Conclusion Waist Liushu acupoint catgut embedding guidance combined with Yaotuibitong capsule is effective to balance the ser-um TNF-αand NO in patients with LIDH, thus to maintain normal vasomotor function, improve local blood supply, alleviate local muscle spasm.