论文部分内容阅读
本文综合整理了近年来国外唐氏征产前筛查研究的资料,目的介绍血清抑制素-A(DIA)单独参与或作为辅助指标均可提高唐氏征筛查的检出率和降低假阳性率。方法用已诊断唐氏综合征的存储血清和对应孕周正常血清进行血清DIA检测和部分临床验证。结果为孕唐氏综合征的孕妇血清DIA明显高于正常孕妇,15～18孕周间其浓度无显著差异且与孕妇体重呈负相关。结论血清DIA是唐氏征产前筛查的敏感指标,含DIA的四联筛查是常规使用的唐氏综合征产前筛查的最有效的方法。
In this paper, a comprehensive review of the data of Down’s pre-election screening studies abroad in recent years, the purpose to introduce Serum inhibin-A (DIA) alone or as an auxiliary index can improve the detection rate of Down’s syndrome screening and reduce the false positive rate. Methods Serum DIA and some clinical tests were performed on stored serum with corresponding Down’s Syndrome and corresponding gestational normal serum. The results of pregnant women with Down Syndrome serum DIA was significantly higher than normal pregnant women, 15 to 18 gestational weeks the concentration was no significant difference and negative correlation with pregnant women body weight. Conclusion Serum DIA is a sensitive indicator of Down’s pre-screening screening. DIA-containing quadruple screening is the most effective method for prenatal screening of Down’s syndrome in routine use.