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目的观察盐酸可乐定干预治疗重症手足口病(HFMD)的临床疗效。方法采取随机、对照的研究方法,将57例重症HFMD患儿随机分为对照组、可乐定治疗组。比较两组患儿在ICU机械通气率、肺水肿/出血发生率、平均ICU入住时间等。结果治疗组与对照组患儿在机械通气率、肺水肿/出血发生率、平均入住ICU时间分别为20.00%、13.33%、(4.13±2.13)d、和44.44%、37.03%、(5.9±2.3)d,两组相比,差异均有统计学意义(P值均<0.05)。结论盐酸可乐定干预治疗重症HFMD,可降低肺水肿/出血发生,减少机械通气,缩短ICU入住时间。
Objective To observe the clinical efficacy of clonidine hydrochloride in the treatment of severe hand-foot-mouth disease (HFMD). Methods A randomized controlled study was conducted in 57 children with severe HFMD who were randomly divided into control group and clonidine group. ICU mechanical ventilation rate, pulmonary edema / bleeding incidence, average ICU stay time and so on were compared between the two groups. Results The rates of mechanical ventilation, pulmonary edema / hemorrhage, and average ICU stay in treatment group and control group were 20.00%, 13.33%, 4.13 ± 2.13 d, 44.44%, 37.03%, 5.9 ± 2.3 ) d, the differences between the two groups were statistically significant (P <0.05). Conclusion Clonidine hydrochloride can significantly reduce the incidence of pulmonary edema / hemorrhage, reduce the mechanical ventilation and shorten the ICU admission time in the treatment of severe HFMD.