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The spin labeled 4(-Epi-N-trifuoroacetyldaunomycin derivatives 6-7 were conveniently synthesized from daunomycin in middle yield. The key steps were the protection of compd. 5 at 9-position and nucleophilic displacement of 5 with R.COOH and DBU at room temperature.
The key steps were the protection of compd. 5 at 9-position and nucleophilic displacement of 5 with R. COOH and DBU at room temperature.