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整合素（Integrins,Itg）是分布在细胞表面的跨膜糖蛋白，属细胞粘附分子，参与细胞一细胞、细胞．细胞外基质的粘附及细胞内外的信号传递。致育素（Fertilin，Frt）是解整合素与金属蛋白酶结构域（ADAMs）基因家族成员，由α，β两个亚基构成，含解整合素（Disintegrin,Dsg）和金属蛋白酶区。Dsg是Itg的配体，能与之结合，而Frtα亚基上的。螺旋结构则参与生物膜的相互融合。卵细胞表面有Itg表达，而成熟精子头的赤道部有Frt分布，推测精子上的Frtβ与卵膜上的Itg结合，使精一卵质膜粘附；而后Frtα使精-卵质膜相互融合；同时，卵膜上的Itg将信号传人细胞内，使卵激活。此外，Itg－Frt结合的特异性可能在防止异种受精及多精受精中起作用，进一步的研究将为不孕症的诊治及新避孕药的研制提供理论依据。
Integrins (Itg) is a transmembrane glycoprotein distributed on the cell surface, which belongs to cell adhesion molecule and participates in cell-cell and cell. Extracellular matrix adhesion and intracellular signaling. Fertilin (Frt) is a member of the family of integrins and metalloproteinases (ADAMs), consisting of two subunits α and β, including Disintegrin (Dsg) and metalloproteinase domains. Dsg is a ligand for Itg that binds to Frtα subunits. Helical structures are involved in biofilm fusion. The expression of Itg on the surface of egg cells and the distribution of Frt in the equator of mature sperm head suggest that Frtβ on sperm binds to Itg on the egg membrane to make the membrane of sperm cell membrane adhere to each other. At the same time, itg on the egg membrane transmits signals into cells, activating the egg. In addition, the specificity of Itg-Frt binding may play a role in preventing heterosis and fertilization. Further research will provide a theoretical basis for the diagnosis and treatment of infertility and the development of new contraceptives.