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前列腺癌严重威胁男性健康,早期诊断缺乏特异性生物标志物。caveolin-1(Cav-1)是一种功能基因,也是胞膜窖的重要外壳结构蛋白,与分子运输,细胞粘附和信号转导等多种细胞功能密切相关,在前列腺癌的发生发展中发挥重要作用。Cav-1可作为生物活性分子在前列腺癌微环境中促进肿瘤增殖和肿瘤血管生成。此外,Cav-1在前列腺癌原发灶及转移灶中均过度表达,尤其是转移灶。目前,Cav-1可在外周血被检测到,其表达水平对提高前列腺癌的诊断有提示意义,与预后相关。本文就Cav-1的结构、生物学特性以及与前列腺癌的相关性进行综述。
Prostate cancer is a serious threat to male health, early diagnosis of the lack of specific biomarkers. Caveolin-1 (Cav-1) is a functional gene and an important outer shell protein of membrane celium. It is closely related to various cellular functions such as molecular transport, cell adhesion and signal transduction. In the development of prostate cancer Play an important role. Cav-1 acts as a bioactive molecule to promote tumor proliferation and tumor angiogenesis in the prostate cancer microenvironment. In addition, Cav-1 is overexpressed in primary and metastatic prostate cancer, especially in metastatic lesions. Currently, Cav-1 can be detected in peripheral blood, the expression level of prostate cancer to improve the diagnosis has prompted significance, and the prognosis. This review summarizes the structure, biological characteristics, and the relationship between Cav-1 and prostate cancer.