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目的探讨左乙拉西坦添加方法治疗在难治性部分性癫痫患者中的应用效果以及对认知功能的影响。方法将新乡市中心医院收治的106例难治性部分性癫痫患者平均分为研究组与对照组。对照组采用托吡酯治疗,研究组给予左乙拉西坦添加治疗,比较两组疗效。结果研究组总有效率为90.57%,显著高于对照组(71.70%,P<0.05)。研究组治疗24周后,延迟记忆、注意及MOCA总分明显高于对照组,且高于基线期时(P<0.05)。两组患者用药期间不良反应对比差异未见统计学意义(P>0.05)。结论左乙拉西坦添加治疗难治性部分性癫痫疗效确切,安全性佳,可以有效降低发作次数,改善患者的认知功能。
Objective To investigate the effect of levetiracetam addition in patients with refractory partial epilepsy and its effect on cognitive function. Methods One hundred and sixty patients with refractory partial epilepsy admitted in Xinxiang Central Hospital were divided equally into study group and control group. The control group was treated with topiramate, the study group was given levetiracetam added treatment, the efficacy of the two groups were compared. Results The total effective rate was 90.57% in the study group, which was significantly higher than that in the control group (71.70%, P <0.05). After 24 weeks of treatment, the scores of delayed memory, attention and MOCA in study group were significantly higher than those in control group (P <0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion Levetiracetam is effective and safe in the treatment of refractory partial epilepsy, which can effectively reduce the number of seizures and improve the cognitive function of patients.