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目的:评价介入化疗合并32P玻璃微球(phosphorus32glassmicrospheres,32PGMS)经支气管动脉栓塞内照射治疗支气管肺癌与单纯介入化疗的疗效.方法:将支气管肺癌48(腺癌9、鳞癌24、腺鳞癌1和小细胞肺癌14)例按入院先后顺序随机分为两组.内放射治疗组在全身化疗2个周期后4wk行支气管动脉灌注化疗和32PGMS经支气管动脉栓塞内照射治疗;传统治疗组在全身化疗2个周期后4wk经支气管动脉灌注化疗.两组的全身化疗方案一致.结果:内放射治疗组完全缓解(CR)5例(21%),部分缓解(PR)15例(62%),稳定(SD)3例(12%),进展(PD)1例(4%),有效率(CR+PR)83%(20/24);而传统治疗组CR2例(8%),PR10例(42%),SD8例(33%),PD4例(17%),RR12例(50%).两组差异明显(83%vs50%,χ2=6.00,P=0.01).而两组术后并发症的发生率无显著差异(8%vs17%,P=0.666).结论:32PGMS经支气管动脉栓塞内照射治疗支气管肺癌的近期疗效优于传统介入组,而不良反应发生率与传统方法无差异.
Objective: To evaluate the efficacy of interventional chemotherapy combined with 32P glass microspheres (32PGMS) by bronchial artery embolization with bronchial artery embolization in patients with bronchial carcinoma and simple interventional chemotherapy.Methods: Bronchial carcinoma 48 (adenocarcinoma 9, squamous cell carcinoma 24, adenosquamous carcinoma 1 And small cell lung cancer 14) were randomly divided into two groups according to the sequence of hospital admission.The internal radiotherapy group in 4 weeks after 2 cycles of systemic chemotherapy bronchial artery infusion chemotherapy and 32PGMS by bronchial artery embolization; conventional treatment group in systemic chemotherapy Four weeks after 2 cycles of transcatheter arterial infusion chemotherapy, the two groups of chemotherapy regimens were identical.Results: In the radiotherapy group, complete remission (CR) occurred in 5 patients (21%) and partial remission (PR) occurred in 15 patients (62% (SD) in 3 cases (12%), progression (PD) in 1 case (4%) and effective rate (CR + PR) (83% vs 50%, χ2 = 6.00, P = 0.01) .But the two groups were complicated by postoperative complications (8% vs 17%, P = 0.666) .Conclusion: The short-term curative effect of 32PGMS with bronchial artery embolization in the treatment of bronchial carcinoma is better than that in the traditional intervention group, and the incidence of adverse reactions and No differences in conventional methods.