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近日,来自中科院生化所和复旦大学的研究人员在国际学术期刊cancer cell在线发表了一项最新研究进展。LKB1基因能够编码丝氨酸/苏氨酸蛋白激酶LKB1,研究发现该激酶可以调节细胞能量代谢、抑制生长增殖和维持细胞极性,而这些都是该基因抑制肿瘤的重要机制。虽然LKB1能够调节细胞生长和能量代谢,但在非小细胞肺癌中,LKB1失活如何协调肿瘤进展与代谢之间的关系仍未可知。在该项研究中,研究人员利用KrasG 12D;Lkb1lox/lox小鼠模型进行了相关研究,发现在肺部恶性腺瘤和鳞状细胞癌中,活性氧(ROS)水平存
Recently, researchers from the Chinese Academy of Sciences and Fudan University biochemists in the international academic journal cancer cell online published a new research progress. LKB1 gene can encode serine / threonine protein kinase LKB1, the study found that the kinase can regulate cell energy metabolism, inhibit growth and maintain cell polarity, and these are important genes in the inhibition of the tumor mechanism. Although LKB1 can regulate cell growth and energy metabolism, it remains unclear how LKB1 inactivation coordinates the relationship between tumor progression and metabolism in non-small cell lung cancer. In this study, researchers used the KrasG 12D; Lkb1lox / lox mouse model and found that reactive oxygen species (ROS) levels in lung adenocarcinomas and squamous cell carcinomas