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目的探讨和观察腹腔热灌注化疗在Ⅱc~Ⅲc期上皮性卵巢癌术后治疗中的临床疗效。方法将符合条件的35例患者随机分为两组,两组患者均采用紫杉醇联合顺铂(DDP)即TP方案进行化疗,其中治疗组(18例)为DDP腹腔热灌注联合紫杉醇静脉双径路化疗,对照组(17例)行标准的TP方案静脉化疗。比较两组复发率和平均无瘤生存时间。结果治疗组3例复发(16.7%),平均无瘤生存时间为治疗后的20.8个月;对照组8例复发(47.1%),平均无瘤生存时间为治疗后的12.2个月。两组间的差异有统计学意义(P<0.05)。结论采用腹腔热灌注联合静脉双径路化疗较单纯静脉化疗疗效更好。
Objective To investigate and observe the clinical efficacy of intraperitoneal hyperthermic perfusion chemotherapy in the postoperative treatment of stage Ⅱc ~ Ⅲc epithelial ovarian cancer. Methods Thirty-five eligible patients were randomly divided into two groups. Patients in both groups received chemotherapy with paclitaxel plus cisplatin (DDP) or TP. The treatment group (18 cases) received intraperitoneal hot perfusion of DDP plus paclitaxel , The control group (17 cases) underwent standard TP regimen intravenous chemotherapy. The recurrence rate and mean tumor-free survival time were compared between the two groups. Results In the treatment group, 3 patients relapsed (16.7%). The mean tumor-free survival time was 20.8 months after treatment. In the control group, 8 patients relapsed (47.1%). The mean tumor-free survival time was 12.2 months after treatment. The difference between the two groups was statistically significant (P <0.05). Conclusion Intraperitoneal hyperthermic perfusion combined with intravenous dual-path chemotherapy is better than simple intravenous chemotherapy.