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应用血清Ⅲ型前胶原（ＰＣⅢ）放免法试剂盒检测急、慢性肝炎及肝硬化患者６１６例血清ＰＣⅢ含量，其中１０２例作了肝活检，病理改变用记分判定。结果发现：与健康对照比较，急性肝炎、慢迁肝、慢活肝及肝硬化患者血清ＰＣⅢ含量均明显升高，差异显著（Ｐ＜０．０５～０．００１）。其升高的血清ＰＣⅢ与肝细胞坏死的范围及门管区炎症程度无相关性（ｒ＝０．４９４；Ｐ＞０．０５），而与肝纤维化程度呈密切正相关（ｒ＝０．６６８；Ｐ＜０．０１）。提示血清ＰＣⅢ测定有助于肝炎，肝硬化时肝纤维化程度的判断。
Serum PCⅢ levels in 616 patients with acute, chronic hepatitis and cirrhosis were detected by serum PC Ⅲ radioimmunoassay kit, 102 of them were biopsied for liver biopsy. The pathological changes were determined by scoring. The results showed that compared with healthy controls, serum PCⅢ levels in acute hepatitis, chronic liver metastasis, chronic liver failure and cirrhosis patients were significantly increased (P <0.05 ~ 0.001). The elevated serum PCⅢ had no correlation with the extent of hepatocellular necrosis and portal inflammation (r = 0.494; P> 0.05), but was positively correlated with the degree of liver fibrosis (r = 0.668 ; P <0.01). Tip serum PC Ⅲ determination contribute to hepatitis, cirrhosis of the degree of liver fibrosis judgment.