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由于抗癌药斑蟊素毒性较大,且化学合成很困难。近来研究证实,去甲斑蟊素和斑蟊素具有同样的药理作用。本实验对斑蟊素的类似物一去甲斑蟊素的合成方法进行了研究,结果发现由呋喃和顺丁烯二酸反应,再经纳化氧化即可制得。并经核磁共振进行元素分析,红外光谱仪进行结构测定,证实此方法所制得的去甲斑蟊素与研究测得的去甲斑蟊素元素及结构相同。此种合成方法简便,成本低廉,为去甲斑蟊素的化学合成开辟了 一条新途径。
Due to the greater toxicity of the anticancer drug cantharidin, and chemical synthesis is difficult. Recent studies have confirmed that norcantharidin and cantharidin have the same pharmacological effects. In this experiment, the synthetic method of cantharidin analogue, norcantharidin, was studied. The results showed that it can be obtained by reaction of furan and maleic acid, and then by oxidation. The elemental analysis was carried out by nuclear magnetic resonance and the structure was measured by an infrared spectrometer. It was confirmed that the norcantharidin obtained by this method is the same as the element and structure of norcantharidin obtained in the study. This method of synthesis is simple, low-cost and opens up a new way for the chemical synthesis of norcantharidin.